(Well, besides the folks who wrote and produced the American Pie trilogy and spawned the dweeb-nookie comedy genre?)
In the last few weeks I've seen a pair of really... interesting takes on Garfield.
Apparently it started with MackJ hypothesizing that Garfield would be really freaky if Garfield himself was silent, like a real cat. There is mention of an older site that did this, but the evidence has been mysteriously destroyed.
It was followed by Garfield Minus Garfield. Be afraid. Be very afraid. Be particularly afraid that entirely empty panels are comedy gold.